Cover Article Cataracts: Another Reason to Lower the IC Dosage
It is well established that systemic corticosteroids increase the risk of cataracts. Now, a new study has shown that inhaled corticosteroids, when used at high doses and for a long duration, also raise the likelihood of cataract development.
Cover Article Getting CAP Patients on Their Feet
Could staying in bed be bad for the health of patients with community-acquired pneumonia (CAP)? Approximately 15% of such patients
require hospitalization, at an annual cost to the US of $4 billion. A team of researchers from Washington University in St. Louis has now found that this simple intervention shortens hospital stays by one day and reduces costs.
Cover Article Rat Allergen and Asthma in the Inner City
Does exposure to rats increase the risk of asthma among inner-city residents? Until recently, this question has received surprisingly little attention. However, new data suggest that rat allergen is common in inner-city homes and that sensitization to it significantly increases asthma morbidity.
Cover Article Arginase Pathway Suggests New Approaches to Asthma Therapy
Gene microarray technology has revealed up-regulation of the enzyme arginase in two distinct models of experimental asthmaand in the lungs of asthma patients. Up-regulation of arginase occurs in response not only to allergens but also to interleukins 4 and 13, cytokines thought to be central to development of the asthma phenotype. The findings point to new targets for asthma therapy.
Cover Article Exploring the Role of Mold in Asthma
Exposure to mold, whether indoors or outdoors, seems to play a part in the development or worsening of respiratory problems, including asthma. Although researchers generally agree that mold affects respiratory health, they are uncertain if it is the mold itself that causes symptoms or the dust mites that flourish in damp environments. Furthermore, if mold is the culprit, exactly how does it affect the lungs?
Cover Article Childhood Asthma Epidemic Reported in Harlem
The Harlem Childrens Zone Asthma Initiative, an ongoing, intensive effort to test and treat for asthma every child living within a 24-block area of Harlem, has revealed an unprecedented asthma prevalence of 25.5%. Although several factors could contribute to this childhood asthma epidemic, clinicians and public health researchers are focusing on how to reduce the shockingly high rate.
Cover Article Asthma Phenotype, Genotype May Guide Future Therapies
The early environment may be important in determining whether a child develops atopy or asthma, but childrens responses to their environment are not all alike: The disease phenotype may be determined by genetic background as well as by exposure.
Cover Article A Close Look at the Clinical Course
As the severe
acute respiratory syndrome (SARS) spreads around the world, physicians
must learn to recognize its early symptoms and to understand its
clinical course. This report provides details about SARSs signs,
symptoms, lab abnormalities, and radiologic findings.
Cover Article Deaths
from Flu and RSV Increasing
Deaths from influenza
and respiratory syncytial virus increased significantly between
1976 and 1999. The elderly segment of the populationthose
65 and olderhad the highest rates of mortality from these
Cover Article Eosinophil
Counts: A Better Marker for Asthma Management
symptoms is necessary for ongoing, efficient disease management.
A new study suggests that using sputum eosinophil counts may be
more effective than using traditional methods to make decisions
on adjusting treatment.
Cover Article COPD
and the Incidence of Osteoporosis
Osteoporosis occurs more frequently in people with COPD than in those with asthma, despite greater corticosteroid use in asthma. This study looks at causative factors in both groups, including low body mass index (BMI), malnutrition, and smokingas well as COPD itself.
Cover Article Can Christopher Reeve Get Off the Ventilator?
Actor Christopher Reeve is making an unprecedented recovery from his 1995 spinal cord injury. He has already regained sensory function in more than 70% of his body as well as 20% of his normal motor function. Now his focus is to breathe entirely on his own. Read about the novel therapy behind his continuing recovery.